| Criterion | Evidence | Decision |
| Risk of bias | Rafiq 2014 was at high risk of performance and detection bias | Serious |
| Imprecision | 7056 participants, 31 events | Serious, few events |
| Inconsistency | Chi2 = 1.35, df = 1 (P = 0.25); I2 = 26% | Serious: the risk of RRT in the control groups was completely different: 0.3% in NAFARM 2011 versus 2.7% in Rafiq 2014 |
| Indirectness | The indications for NSAID was prevention of atrial fibrillation in the largest study (NAFARM 2011) rather than analgesia | Serious because the dose of naproxen in NAFARM 2011 was much lower than would be used for analgesia |
| Publication bias | None of the studies were commercially sponsored | Not serious |
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