| Criterion | Evidence | Decision |
| Risk of bias | Rafiq 2014 was at high risk of performance and detection bias | Serious |
| Imprecision | 312 participants, 8 events | Serious: few events |
| Inconsistency | Chi2 = 1.61, df = 1 (P = 0.20); I2 = 39% | Serious: the relative risk of death was in opposite directions: 3.85 in NAFARM 2011 versus 0.48 in Rafiq 2014 |
| Indirectness | The indications for NSAID was prevention of atrial fibrillation in the largest study (NAFARM 2011) rather than analgesia | Serious: the dose of naproxen in NAFARM 2011 was much lower than would be used for analgesia |
| Publication bias | None of the studies were commercially sponsored | Not serious |
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