Criterion | Evidence | Decision |
Risk of bias | Rafiq 2014 was at high risk of performance and detection bias; Kulik 2004 was at high risk of attrition bias | Serious |
Imprecision | 410 participants | Not serious: length of stay measured in all participants |
Inconsistency | Chi2 = 2.63, df = 1 (P = 0.27); I2 = 24% | Serious: mean length of stay in control groups varied from 5.4 (Kulik 2004) to 17.2 days (NAFARM 2011) |
Indirectness | The indications for NSAID was prevention of atrial fibrillation in the largest study (NAFARM 2011) rather than analgesia | Serious: the dose of naproxen in NAFARM 2011 was much lower than would be used for analgesia |
Publication bias | None of the studies were commercially sponsored | Not serious |