. 2018 Oct 30;2018(10):CD009764. doi: 10.1002/14651858.CD009764.pub3

1. Summary of study characteristics.

Study	Country	No. of patients	Age (range unless otherwise stated)	% predicted FEV1 (range ) unless otherwise stated	Intervention	Comparator	Duration of treatment
Albert 2011	United States of America	1142	65 ‐ 66	39 ‐ 40	Azithromycin 250 mg daily	Placebo	12 months
Banerjee 2005	United Kingdom	67	65.1 ‐ 68.1	42.5 ‐ 43.9	Clarithromycin ‐ long‐acting Klaricid XL 500 mg daily	Placebo	3 months
Berkhof 2013	Netherlands	84	67 ‐ 68	47.4 ‐ 49.8	Azithromycin 250 mg 3 times a week	Placebo	12 weeks
Brill 2015	United Kingdom	99	67.9 ‐ 70.4	44 ‐ 53	Moxifloxacin 400 mg/day for 5 days every 4 weeks	Placebo	13 weeks
					Doxycycline 100 mg daily
					Azithromycin 250 mg 3 times a week
He 2010	China	36	68.8 ‐ 69.3	42.1 ‐ 44.3	Erythromycin 125 mg 3 times a day	Placebo	6 months
Mygind 2010	Denmark	575	71 (median)	38.4 (median)	Azithromycin 500 mg 3 days a month	Placebo	36 months
NCT00524095 (terminated; details given represent proposal)	Italy	210	45 ‐ 85	N/A	Azithromycin 500 mg 3 times a week for 6 months, then fluticasone 500 μg twice a day for 6 months	Usual care	1 year
NCT00524095 (terminated; details given represent proposal)	Italy	210	45 ‐ 85	N/A	Fluticasone 500 μg twice a day for 6 months, then azithromycin 500 mg 3 times a week for 6 months	Usual care	1 year
NCT02628769 (terminated; details given represent proposal)	United Kingdom	5	N/A	N/A	Solithromycin 400 mg daily	Placebo	28 days
Seemungal 2008	United Kingdom	109	66 ‐ 68	49.25 ‐ 50.55	Erythromycin 250 mg twice a day	Placebo	12 months
Sethi 2010	International	1157	66.1 ‐ 66.6	40.6 ‐ 42.2	Moxifloxacin 400 mg daily for 5 days every 8 weeks	Placebo	48 weeks
Shafuddin 2015	Australia & New Zealand	292	65.8 ‐ 67.6	32.53 ‐ 35.8	Roxithromycin 300 mg daily and Doxycycline 100 mg daily	Placebo	12 weeks
Shafuddin 2015	Australia & New Zealand	292	65.8 ‐ 67.6	32.53 ‐ 35.8	Roxithromycin 300 mg daily	Placebo	12 weeks
Simpson 2014	Australia	30	69.9 ‐ 71.1	51.1 ‐ 56.5	Azithromycin 250 mg daily	Placebo	12 weeks
Suzuki 2001	Japan	109	69.1 ‐ 71.7	1.3 ‐ 1.47 L	Erythromycin 200 ‐ 400 mg daily	Riboflavin 10 mg daily	Unclear
Tan 2016	China	54	67.3 ‐ 69.3	42.1 ‐ 46.5	Erythromycin 125 mg 3 times a day for 12 months	Placebo	12 months
Tan 2016	China	54	67.3 ‐ 69.3	42.1 ‐ 46.5	Erythromcyin 125 mg 3 times a day for 6 months	Placebo	12 months
Uzun 2014	Netherlands	92	64.7 ‐ 64.9	44.2 ‐ 45	Azithromycin 500 mg three times a week	Placebo	12 months
Wang 2017	China	86	70.54 ‐ 72.43	Unclear	Azithromycin 250 mg daily	Simvastatin 20 mg daily	6 months

FEV1: forced expiratory volume in one second.