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. 2018 Oct 30;2018(10):CD009764. doi: 10.1002/14651858.CD009764.pub3

Comparison 2. Subgroup analyses.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Subgroup analysis: number of people with one or more exacerbations by mean % predicted FEV1 8 2716 Odds Ratio (M‐H, Random, 95% CI) 0.57 [0.42, 0.78]
1.1 Mean FEV1 % ≥ 50 1 30 Odds Ratio (M‐H, Random, 95% CI) 0.24 [0.05, 1.13]
1.2 Mean FEV1 % < 50 7 2686 Odds Ratio (M‐H, Random, 95% CI) 0.60 [0.44, 0.81]
2 Subgroup analysis: number of people with one or more exacerbations by treatment duration 8 2716 Odds Ratio (M‐H, Random, 95% CI) 0.57 [0.42, 0.78]
2.1 ≥ 3 months to < 6 months 3 213 Odds Ratio (M‐H, Random, 95% CI) 0.51 [0.28, 0.94]
2.2 ≥ 6 months to < 12 months 2 1185 Odds Ratio (M‐H, Random, 95% CI) 0.63 [0.24, 1.69]
2.3 ≥ 12 months 3 1318 Odds Ratio (M‐H, Random, 95% CI) 0.45 [0.25, 0.81]
3 Subgroup analysis: number of people with one or more exacerbations by year carried out 8 2716 Odds Ratio (M‐H, Random, 95% CI) 0.57 [0.42, 0.78]
3.1 2005 to 2009 1 109 Odds Ratio (M‐H, Random, 95% CI) 0.37 [0.17, 0.84]
3.2 2010 to 2014 6 2508 Odds Ratio (M‐H, Random, 95% CI) 0.57 [0.39, 0.83]
3.3 2015 to 2019 1 99 Odds Ratio (M‐H, Random, 95% CI) 0.74 [0.29, 1.89]
4 Subgroup analysis: number of people with one or more exacerbations by regimen 8 2716 Odds Ratio (M‐H, Random, 95% CI) 0.57 [0.42, 0.78]
4.1 Once daily antibiotic 3 1180 Odds Ratio (M‐H, Random, 95% CI) 0.61 [0.34, 1.09]
4.2 Twice or three times daily antibiotic 2 145 Odds Ratio (M‐H, Random, 95% CI) 0.35 [0.17, 0.71]
4.3 Three times a week antibiotic 3 209 Odds Ratio (M‐H, Random, 95% CI) 0.39 [0.19, 0.77]
4.4 Pulsed antibiotic 2 1182 Odds Ratio (M‐H, Random, 95% CI) 0.85 [0.68, 1.07]
5 Subgroup analysis: number of people with one or more exacerbations by exacerbation history 8 2716 Odds Ratio (M‐H, Random, 95% CI) 0.57 [0.42, 0.78]
5.1 Inclusion criteria of ≥ 1 exacerbation in preceding year 3 2358 Odds Ratio (M‐H, Random, 95% CI) 0.66 [0.43, 0.99]
5.2 Exacerbation history not an inclusion criteria 5 358 Odds Ratio (M‐H, Random, 95% CI) 0.44 [0.27, 0.69]