Date	Event	Description
21 September 2005	New search has been performed	This review is an update of the review published in 2004, Issue 4 (second update). A highly sensitive search applying the same search strategy as used for the original review was performed from 01 October 2003 to 21 September 2005 (adding the search terms for glulisine, which is new on the market): 386 potentially relevant abstracts were identified and screened. 375 of these were excluded by consensus. Eleven publications were potentially appropriate for this review, 4 of which were excluded by consensus because they were not randomised, had no comparable insulin regimens, or analogues were not compared with regular insulin. Finally, seven new studies fulfilled the inclusion criteria. For further details, see figure 9 presenting the flow chart according to the QUOROM statement. After including the 7 new studies in the analyses, the conclusion from the first review remained unchanged.
31 December 2003	New search has been performed	first update