Trial ID	Intervention(s) and comparator(s)	Duration of intervention	Description of participants	Trial period (year to year)	Country	Setting	Ethnic groups (%)	Duration of diabetes (mean years (SD))
Altuntas 2003	I: insulin lispro	6 months	Insulin naive participants with type 2 diabetes with OAD failure	—	Turkey	—	—	6
	C: RHI							10
Bastyr 2000	I: insulin lispro	12 months	Adults participants with type 2 diabetes who had started insulin therapy within the last two months	1993‐1994	USA, Europe, Canada, South Africa	Multicentre	Clinical trial participants: White: 76 North Americans: 73 Subset of clinical trial participants who completed HRQoL: White: 79 North Americans: 100	8
	C: RHI							8
Dailey 2004	I: insulin glulisine	26 weeks	Participants with type 2 diabetes who had been on insulin treatment for at least 6 months	—	Australia, Canada, USA	Multicentre	White: 86 Black: 11 Asian: 2 Multiethnic: 2 Hispanic: 8	15 (8)
	C: RHI						White: 85 Black: 12 Asian: 2 Multiethnic: 1 Hispanic: 6	13 (8)
Hermann 2013	I: insulin aspart	24 months	Insulin naive type 2 diabetic participants who have been treated with oral antidiabetic medication	—	Germany	Multicentre	—	—
	C: RHI						—	—
NCT01650129	I: biphasic insulin aspart 50	24 weeks	Participants with type 2 diabetes who had been on insulin treatment for at least 24 weeks	2001	Japan	Multicentre	—	—
	C: biphasic human insulin 50/50						—	—
Pfützner 2013	I1: insulin aspart	6 months	Participants with type 2 diabetes	—	Germany	—	—	—
	I2: insulin glulisine						—	—
	C: RHI						—	—
Rayman 2007	I: insulin glulisine	26 weeks	Participants with type 2 diabetes who had been on insulin treatment for at least 6 months	2001‐2003	Multinational study in 22 countries (Europe, Oceania, Argentinia, South Africa, Israel)	Multicentre	—a	14 (8)
	C: RHI						—a	13 (7)
Ross 2001	I: insulin lispro	5.5 months	Insulin naive participants with type 2 diabetes after failure to respond to sulphonylurea	—	Canda	—	—	11 (8)
	C: RHI						—	11 (7)
Z012 1997	I: insulin lispro	12 months	Participants with type 2 diabetes who have been on insulin therapy for at least 2 months	1992‐1993	USA, South Africa, Belgium, Canada	Multicentre, outpatient	—	11
	C: RHI						—	12
Z014 1997	I: insulin lispro	12 months	Participants with type 2 diabetes who have been on insulin therapy for at least 2 months	1992‐1993	USA, South Africa, Belgium, Canada	Multicentre, outpatient	—	14
	C: RHI						—	12
aMore Hispanic participants in the RHI group —: denotes not reported C: comparator; HRQoL: health‐related quality of life questionnaire; I: intervention; OAD: oral antidiabetic drug; SD: standard deviation