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. 2018 Oct 29;2018(10):CD011510. doi: 10.1002/14651858.CD011510.pub2

NCT02385422.

Trial name or title The effect of carvedilol vs propranolol in cirrhotic participants with variceal bleeding
Methods To compare the efficacy and safety of carvedilol and propranolol in participants with cirrhosis‐related oesophagogastric varices after multiple endoscopic treatments for secondary prophylaxis
Participants will receive an endoscopic examination after they have been followed up on trial drug for 6 months, and if they have recurrence of varices or deterioration of varices, they are considered to be in need of endoscopic re‐treatment
Participants Cirrhotic participants with gastroesophageal varices confirmed by endoscopy sub classified at the time of recruitment as having 1) mild oesophageal varices; 2) gastric varices with a diameter < 5 mm; or 3) variceal eradication at the time of recruiting; history of variceal bleeding treated on at least 3 occasions by variceal banding
Interventions
  • Carvedilol

  • Propranolol

Outcomes Primary outcome:
  • endoscopic re‐treatment


Secondary outcomes:
  • rebleeding rate

  • mortality rate

  • adverse events

Starting date March 2015
Contact information chen.shiyao@zs‐hospital.sh.cn
Notes We contacted trial authors for unpublished data in May 2017 but they have yet to respond