Comparison 2. Active topical agent versus placebo/control.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Pressure ulcer	4		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 Active lotion versus placebo	1	167	Risk Ratio (M‐H, Fixed, 95% CI)	0.73 [0.45, 1.19]
1.2 DSMO cream versus placebo	1	61	Risk Ratio (M‐H, Fixed, 95% CI)	1.99 [1.10, 3.57]
1.3 Conotrane versus placebo	1	258	Risk Ratio (M‐H, Fixed, 95% CI)	0.74 [0.52, 1.07]
1.4 Prevasore versus control	1	120	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.04, 3.11]
2 Pressure ulcer stage	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 Stage 3	1	258	Risk Ratio (M‐H, Fixed, 95% CI)	1.25 [0.34, 4.55]
2.2 Stage 4	1	258	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.01, 8.11]
3 Adverse event	1	167	Odds Ratio (M‐H, Fixed, 95% CI)	6.14 [0.29, 129.89]