Skip to main content
. 2018 Oct 1;2018(10):CD002252. doi: 10.1002/14651858.CD002252.pub4

Australia 1983.

Methods Allocation concealment: not stated. Authors state "randomly allocated". Two arms
Participants 28 women in antenatal clinics with mild‐moderate PIH (BP >/= 140/90 mmHg x 2 at least 24 hrs apart).
 Excluded: impaired renal function.
Interventions Exp: oral propranolol 30 mg/day 160 mg/day. (14 women)
 Control: oral methyldopa 500 mg/day to1000 mg/day. (14 women)
Outcomes Women: severe HT, proteinuria (undefined), additional antihypertensive, changed drugs due to side‐effects, caesarean section.
 Babies: perinatal death, preterm delivery, jaundice, bradycardia, hypoglycaemia, birthweight (mean).
Notes London School of Hygiene sphygmomanometer (random zero) used. No mention of which Korotkoff sound used for DBP.
Funding: no information about funding source.
Declaration of interests not described.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Not described.
Allocation concealment (selection bias) Unclear risk Not described: quote "...randomly allocated..." no further details.
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Open‐label trial.
Blinding of outcome assessment (detection bias) 
 All outcomes High risk No.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No.
Selective reporting (reporting bias) Unclear risk Assessment from published study report.
Other bias Unclear risk No information about funding source. Declaration of interests not described