Australia 1983.
Methods | Allocation concealment: not stated. Authors state "randomly allocated". Two arms | |
Participants | 28 women in antenatal clinics with mild‐moderate PIH (BP >/= 140/90 mmHg x 2 at least 24 hrs apart). Excluded: impaired renal function. | |
Interventions | Exp: oral propranolol 30 mg/day 160 mg/day. (14 women) Control: oral methyldopa 500 mg/day to1000 mg/day. (14 women) | |
Outcomes | Women: severe HT, proteinuria (undefined), additional antihypertensive, changed drugs due to side‐effects, caesarean section. Babies: perinatal death, preterm delivery, jaundice, bradycardia, hypoglycaemia, birthweight (mean). | |
Notes | London School of Hygiene sphygmomanometer (random zero) used. No mention of which Korotkoff sound used for DBP. Funding: no information about funding source. Declaration of interests not described. |
|
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not described. |
Allocation concealment (selection bias) | Unclear risk | Not described: quote "...randomly allocated..." no further details. |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Open‐label trial. |
Blinding of outcome assessment (detection bias) All outcomes | High risk | No. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No. |
Selective reporting (reporting bias) | Unclear risk | Assessment from published study report. |
Other bias | Unclear risk | No information about funding source. Declaration of interests not described |