Brazil 1988.

Methods	Allocation concealment: consecutive numbered treatment boxes. Two arms
Participants	40 pregnant women with chronic HT with DBP =/> 95 mmHg, without proteinuria.
Interventions	Exp: oral pindolol 10 mg/day to 30 mg/day. (20 women) Control: oral methyldopa 500 mg/day to 2000 mg/day. (20 women)
Outcomes	Women: BP, need for additional antihypertensives, severe HT, superimposed PE. Babies: birthweight, Apgar score, fetal and neonatal death, preterm birth, SGA (undefined).
Notes	Main paper in Portuguese. Methods for measuring BP not mentioned. Additional data provided by authors. Funding: no information about funding source. Declaration of interests not declared
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not stated.
Allocation concealment (selection bias)	Low risk	Consecutive numbered treatment boxes (personal communication).
Blinding of participants and personnel (performance bias) All outcomes	High risk	Open‐label trial.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No.
Selective reporting (reporting bias)	Low risk	Published and unpublished data provided by author.
Other bias	Unclear risk	No information about funding source. Declaration of interests not described.