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. 2018 Oct 1;2018(10):CD002252. doi: 10.1002/14651858.CD002252.pub4

France 1988a.

Methods Allocation concealment: not stated. Authors state "random order".
 3‐arm study, the two beta blocker arms were combined for the analysis.
Participants 63 women at 7‐36 weeks' gestation with DBP > 90 mmHg x 2, 8 days apart).
Interventions Exp: (1) oral acebutolol 400 mg to 1200 mg (21 women); (2) oral labetalol 400 mg to 1200 mg (21 women).
 Control: oral methyldopa 500 mg to 1500 mg (21 women).
Outcomes Women: PE, caesarean section. 
 Babies: perinatal death, preterm delivery, birthweight (mean), Apgar, admission to SCBU, hypoglycaemia.
Notes No mention about Korotkoff sound considered for DBP. Main paper in French.
Funding: no information about funding source.
Declaration of interests not described.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "Apres tirage au sort, effectué par groupe de 9 patientes..."
Allocation concealment (selection bias) Unclear risk Not described.
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Open‐label trial.
Blinding of outcome assessment (detection bias) 
 All outcomes High risk No.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No.
Selective reporting (reporting bias) Unclear risk Assessment from published study report.
Other bias Unclear risk Groups appear comparable at baseline. No information about funding source.
Declaration of interests not described.