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. 2018 Oct 1;2018(10):CD002252. doi: 10.1002/14651858.CD002252.pub4

Ireland 1991.

Methods Allocation concealment: cards with 'test' or 'control' sealed in envelopes, shuffled and then numbered in sequence. Consecutive envelopes opened.Two arms
Participants 36 women < 38 weeks' gestation with BP >/= 140/90 mmHg on 2 separate days, without proteinuria.
 Excluded: if lived too far from the hospital to attend for frequent examinations.
Interventions Exp: choice between oral atenolol 50 mg/day to 100 mg/day and oral methyldopa 750 mg/day to 2250 mg/day. If monotherapy inadequate, 2 drugs combined. Oral bendrofluazide 2.5 mg to 5.0 mg added as a third agent when necessary. (17 women)
 Control: no antihypertensive. (19 women)
Outcomes Women: MAP, proteinuria. 
 Babies: perinatal death, Apgar, gestation age at delivery, birthweight, birthweight < 50th centile.
Notes Korotkoff phase V used for DBP. Additional data provided by authors.
Funding: no information about funding source.
Declaration of interests not described.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) High risk Quote: "...shuffled into random order..."
Allocation concealment (selection bias) Low risk Sealed, identical numbered envelopes.
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Open‐label trial.
Blinding of outcome assessment (detection bias) 
 All outcomes High risk No.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No.
Selective reporting (reporting bias) Unclear risk Assessment from published study report.
Other bias Unclear risk Groups appear comparable at baseline. No information about funding source. Declaration of interests not described.