Ireland 1991.
Methods | Allocation concealment: cards with 'test' or 'control' sealed in envelopes, shuffled and then numbered in sequence. Consecutive envelopes opened.Two arms | |
Participants | 36 women < 38 weeks' gestation with BP >/= 140/90 mmHg on 2 separate days, without proteinuria. Excluded: if lived too far from the hospital to attend for frequent examinations. | |
Interventions | Exp: choice between oral atenolol 50 mg/day to 100 mg/day and oral methyldopa 750 mg/day to 2250 mg/day. If monotherapy inadequate, 2 drugs combined. Oral bendrofluazide 2.5 mg to 5.0 mg added as a third agent when necessary. (17 women) Control: no antihypertensive. (19 women) | |
Outcomes | Women: MAP, proteinuria. Babies: perinatal death, Apgar, gestation age at delivery, birthweight, birthweight < 50th centile. | |
Notes | Korotkoff phase V used for DBP. Additional data provided by authors. Funding: no information about funding source. Declaration of interests not described. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | High risk | Quote: "...shuffled into random order..." |
Allocation concealment (selection bias) | Low risk | Sealed, identical numbered envelopes. |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Open‐label trial. |
Blinding of outcome assessment (detection bias) All outcomes | High risk | No. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No. |
Selective reporting (reporting bias) | Unclear risk | Assessment from published study report. |
Other bias | Unclear risk | Groups appear comparable at baseline. No information about funding source. Declaration of interests not described. |