Sweden 1984.
Methods | Allocation concealment: telephone randomisation, no further details. Two arms | |
Participants | 52 women in antenatal clinic at < 37 weeks' gestation with singleton pregnancy, BP >/= 140/90 mmHg or an increase of at least 30 mmHg SBP or 15 mmHg DBP x 2 within 24 hrs. Excluded: imminent eclampsia, serious fetal distress, severe HT (> 170/110 mmHg), Rh disease, diabetes, contraindication to beta blockers, 'social or psychological handicaps'. | |
Interventions | Exp: oral metoprolol 100 mg x 2/day to 200 mg x 2/day. (26 women) Control: oral identical placebo x 2/day.(26 women) | |
Outcomes | Women: proteinuria (>/= 2+), severe HT, changed drugs due to side‐effects, hospital admission, placental abruption, caesarean section. Babies: perinatal death, gestation at delivery (mean) Apgar (mean). | |
Notes | Korotkoff phase V used for DBP. Additional data provided by authors. Funding: funded by charity or foundation. Declaration of interests not described. |
|
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not described. |
Allocation concealment (selection bias) | Low risk | Telephone randomisation (personal communication). |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | Double‐blind. Placebos of identical appearance. |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | Yes. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No. |
Selective reporting (reporting bias) | Low risk | Unpublished data provided by author. |
Other bias | Unclear risk | Declaration of interests not described. Funded by charity or foundation. |