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. 2018 Oct 1;2018(10):CD002252. doi: 10.1002/14651858.CD002252.pub4

Sweden 1984.

Methods Allocation concealment: telephone randomisation, no further details. Two arms
Participants 52 women in antenatal clinic at < 37 weeks' gestation with singleton pregnancy, BP >/= 140/90 mmHg or an increase of at least 30 mmHg SBP or 15 mmHg DBP x 2 within 24 hrs.
 Excluded: imminent eclampsia, serious fetal distress, severe HT (> 170/110 mmHg), Rh disease, diabetes, contraindication to beta blockers, 'social or psychological handicaps'.
Interventions Exp: oral metoprolol 100 mg x 2/day to 200 mg x 2/day. (26 women)
 Control: oral identical placebo x 2/day.(26 women)
Outcomes Women: proteinuria (>/= 2+), severe HT, changed drugs due to side‐effects, hospital admission, placental abruption, caesarean section.
 Babies: perinatal death, gestation at delivery (mean) Apgar (mean).
Notes Korotkoff phase V used for DBP. Additional data provided by authors.
Funding: funded by charity or foundation.
Declaration of interests not described.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Not described.
Allocation concealment (selection bias) Low risk Telephone randomisation (personal communication).
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk Double‐blind. Placebos of identical appearance.
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk Yes.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No.
Selective reporting (reporting bias) Low risk Unpublished data provided by author.
Other bias Unclear risk Declaration of interests not described. Funded by charity or foundation.