TABLE 5.

Associations between PRBC age, major transfusion-related adverse events and 30-day death

PRBC Age Category	≥2 Adverse Events or 24-Hour Death OR (95% CI)	≥2 Adverse Events or 24-Hour Death OR (95% CI)	30-Day Death OR (95% CI)	30-Day Death OR (95% CI)
PRBC Volume (Units) as Continuous Variable
0–7 days	1.08 (0.995–1.17)		1.00 (0.91–1.11)
8–14	1.13 (1.06–1.19)		1.03 (0.98–1.08)
15–21	1.08 (1.03–1.14)		1.06 (1.02–1.10)
22+	1.11 (1.07–1.16)		1.09 (1.04–1.12)
PRBC Volume (Units) as Categorical Variable
0–7 days
0 units		Referent		Referent
1–10		0.87 (0.57–1.33)		0.95 (0.56–1.63)
11–20		N/A		N/A
21+		1.02 (0.13–8.32)		0.44 (0.01–21.29)
8–14 days
0 units		Referent		Referent
1–10		1.80 (1.20–2.69)		1.42 (0.81–2.50)
11–20		2.87 (1.07–7.73)		1.98 (0.70–5.59)
21+		3.90 (0.64–23.84)		2.20 (0.19–25.47)
15–21 days
0 units		Referent		Referent
1–10		0.94 (0.64–1.37)		1.15 (0.67–1.96)
11–20		3.35 (0.90–12.52)		1.66 (0.49–5.59)
21+		2.23 (0.58–8.51)		4.49 (1.38–14.65)
22+ days
0 units		Referent		Referent
1–10		1.62 (1.05–2.52)		1.90 (1.003–3.58)
11–20		4.48 (2.08–9.68)		12.46 (5.09–30.51)
21+		6.83 (2.24–20.81)		5.11 (1.59–16.41)

Odds ratios (OR) estimated from random effects models, adjusted for patient age, sex, race, mechanism of injury, Injury Severity Score, Revised Trauma Score, total PRBC units transfused in the first 24 hours after admission, PROPPR trial treatment group, and accounting for clustering by study site. PRBC = packed red blood cell.