4. Analysis by observer experience for detection of invasive melanoma or atypical intraepidermal melanocytic variants.
| Test | Studies |
Lesions (cases) |
DOR (95% CI) |
Specificity at 80% sensitivity (95% CI) % |
Sensitivity at 80% specificity (95% CI) % |
RDOR (95% CI) |
P‐value (LR) |
| Experience: in‐person | |||||||
| NR | 10 | 8390 (1015) |
97.7 (35.6 to 268) |
97% (90 to 99) |
94% (87 to 98) |
1.9 (0.49 to 7.1) |
0.64 |
| High | 14 | 14,213 (612) |
52.4 (21.6 to 127) |
94% (84 to 98) |
91% (83 to 96) |
1.00 (comparator) |
|
| Trained | 2 | 566 (37) |
19.2 (1.6 to 226) |
82% (19 to 99) |
82% (36 to 97) |
0.37 (0.03 to 5.1) |
|
| Experience: image‐based | |||||||
| NR | 11 | 2777 (465) |
35.4 (15.9 to 78.7) |
90% (80 to 96) |
89% (80 to 95) |
2.0 (0.8 to 4.9) |
< 0.001 |
| High | 34 | 8933 (1956) |
17.2 (11.8 to 26.5) |
82% (74 to 87) |
81% (75 to 86) |
1.00 (comparator) |
|
| Moderate | 5 | 678 (193) |
11.3 (5.9 to 21.3) |
73% (58 to 85) |
74% (61 to 84) |
0.64 (0.37 to 1.1) |
|
| Low | 6 | 448 (123) |
5.3 (2.6 to 10.8) |
55% (35 to 73) |
58% (41 to 74) |
0.30 (0.15 to 0.58) |
|
| Mixed | 5 | 473 (117) |
4.4 (1.4 to 13.5) |
50% (23 to 77) |
54% (29 to 78) |
0.25 (0.07 to 0.81) |
|
| Trained | 11 | 1087 (240) |
9.0 (4.5 to 17.9) |
68% (51 to 81) |
70% (55 to 82) |
0.15 (0.25 to 1.02) |
|
| CI: confidence interval; DOR: diagnostic odds ratio; LR: likelihood ratio test; NR: not reported; RDOR: relative diagnostic odds ratio | |||||||