| Test |
Studies |
Lesions (cases) |
DOR (95% CI) |
Specificity at 80% sensitivity (95% CI) % |
Sensitivity at 80% specificity (95% CI) % |
RDOR (95% CI) |
| All in‐person evaluations |
| Visual inspection |
13 |
6740 (459) |
13.1 (7.0 to 24.5) |
75% (57 to 87) |
76% (66 to 85) |
4.7 (3.0 to 7.5) |
| Visual inspection + dermoscopy |
26 |
23,169 (1664) |
61.7 (34.9 to 109) |
95% (90 to 98) |
92% (87 to 95) |
‐ |
| Change with adding dermoscopy to visual inspection (95% CI) |
‐ |
‐ |
‐ |
+20% (+7 to +33) |
+16% (+8 to +23) |
‐ |
| In‐person evaluations: direct comparison |
| Visual inspection |
11 |
5854 (412) |
13.7 (5.9 to 31.8) |
75% (49 to 90) |
77% (63 to 87) |
4.8 (2.8 to 8.1) |
| Visual inspection + dermoscopy |
11 |
5854 (412) |
65.7 (27.0 to 160) |
95% (87 to 99) |
92% (84 to 96) |
‐ |
| Change with adding dermoscopy to visual inspection (95% CI) |
‐ |
‐ |
‐ |
+21% (+2 to +39) |
+15% (+7 to +23) |
‐ |
| In‐person evaluations: with histology and follow‐up for those not having surgery |
| Visual inspection |
2 |
3607 (60) |
18.4 (2.63 to 128) |
82% (39 to 97) |
82% (40 to 97) |
14.4 (4.4 to 47.6) |
| Visual inspection + dermoscopy |
6 |
17,574 (800) |
265 (49 to 1428) |
99% (91 to 100) |
98% (87 to 100) |
‐ |
| Change with adding dermoscopy to visual inspection (95% CI) |
‐ |
‐ |
‐ |
+16% (‐23 to 56) |
+16% (‐20 to 53) |
‐ |
| In‐person evaluations with low risk of bias for the index test |
| Visual inspection |
4 |
3957 (176) |
16.9 (6.1 to 46.8) |
80% (52 to 94) |
80% (63 to 91) |
3.1 (1.3 to 7.4) |
| Visual inspection + dermoscopy |
20 |
19182 (831) |
53.0 (25.8 to 109) |
94% (87 to 98) |
91% (84 to95) |
‐ |
| Change with adding dermoscopy to visual inspection (95% CI) |
‐ |
‐ |
‐ |
+14% (‐6 to +34) |
+11% (‐1 to +23) |
‐ |
| In‐person evaluations with low risk of bias for the reference test |
| Visual inspection |
10 |
2802 (367) |
13.8 (7.3 to 26.3) |
76% (59 to 87) |
77% (67 to 85) |
4.2 (2.5 to 7.1) |
| Visual inspection + dermoscopy |
20 |
7636 (1418) |
57.8 (32.2 to 104) |
95% (89 to 97) |
92% (87 to 95) |
‐ |
| Change with adding dermoscopy to visual inspection (95% CI) |
‐ |
‐ |
‐ |
+19% (+5 to +32) |
+15% (+6 to +23) |
‐ |
| In‐person evaluations with low risk of bias for flow and timing |
| Visual inspection |
2 |
601 (66) |
11.0 (2.7 to 44.4) |
61% (26 to 87) |
73% (55 to 85) |
5.1 (1.2 to 20.9) |
| Visual inspection + dermoscopy |
4 |
984 (113) |
55.7 (24.4 to 127) |
95% (85 to 98) |
88% (79 to 94) |
‐ |
| Change with adding dermoscopy to visual inspection (95% CI) |
‐ |
‐ |
‐ |
+34% (‐45 to +100) |
+16% (‐28 to +60) |
‐ |
| In‐person evaluations excluding case‐control studies |
| Visual inspection |
13 |
6740 (459) |
13.1 (7.0 to 24.5) |
75% (57 to 87) |
76% (66 to 85) |
4.7 (3.0 to 7.5) |
| Visual inspection + dermoscopy |
26 |
23,169 (1664) |
61.7 (34.9 to 109) |
95% (90 to 98) |
92% (87 to 95) |
‐ |
| Change with adding dermoscopy to visual inspection (95% CI) |
‐ |
‐ |
‐ |
+20% (+7 to +33) |
+16% (+8 to +23) |
‐ |
|
CI: confidence interval; DOR: diagnostic odds ratio; RDOR: relative diagnostic odds ratio |
