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. 2019 May 3;10(33):3104–3113. doi: 10.18632/oncotarget.5742

Figure 3. TOX and PLS3 expression following drug treatment.

Figure 3

a. Effects of therapy on gene expression in vitro. Expression of both TOX and PLS3 in SS PBMCs normalizes with in vitro romidepsin (R) treatment but not pralatrexate (P) following 48-hour culture. Control samples (no tx) were patient PBMCs cultured in media with no drug for 48 hours. b. Gene expression changes in vivo. TOX and PLS3 expression also normalized in CD4+ T-cells isolated from patients with partial or complete disease resolution following treatment with romidepsin. All pooled data is shown as mean +/− SEM.