Table 1. Genes selected for reverse transcriptase analysis.

Gene	SS to Norm	MF to Norm	Biological Relevance
T-plastin (PLS3)	83.00	12.00	PLS3 is an actin-building protein not normally expressed in T-cells [34]. It has a role in SS cell survival, and migration [31].
Thymocyte selection associated high mobility group box protein (TOX)	21.47	1.38	TOX is a transcription factor highly expressed in the thymus necessary for the development of CD4+ cells but not normally expressed in mature CD4+ cells [16].
Killer cell Ig-like receptor 3DL2 (KIR3DL2)	19.67	n/a	KIR3DL2 inhibits natural killer–mediated lysis after interaction with HLA-A, may prevent elimination of tumor cells [36].
Integrin β1 (ITGB1)	16.67	3.19	Integrins play a role in cellular shape, motility and the cell cycle [37]. In SS, ITGB1 may increase skin homing [38].
Programmed Cell Death 6 (PDCD6)	13	0.16	PDCD6 product participates in T-cell receptor-programmed cell death and may have a role in cancer survival pathways [39].

Ratios of overexpression comparing SS CD4+ cells to normal CD4+ cells as well as MF lesional skin to normal CD4+ cells as determined by previously reported sequence-based analysis are displayed as well as biological significance.