Comparison 1. Primary outcomes.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Overall survival	6	3993	Hazard Ratio (Random, 95% CI)	1.04 [0.86, 1.25]
2 Recurrence free survival	5	3710	Hazard Ratio (Random, 95% CI)	1.14 [0.90, 1.43]