Summary of findings 2. Scheduled PDE5I compared to on demand placebo or no treatment for post‐prostatectomy erectile dysfunction (long‐term).
| Scheduled PDE5I compared to on demand placebo or no treatment for post‐prostatectomy erectile dysfunction (long‐term) | |||||
| Patient or population: post‐prostatectomy erectile dysfunction (long‐term) Setting: outpatient clinic Intervention: scheduled PDE5I Comparison: on demand placebo or no treatment | |||||
| Outcomes | № of participants (studies) Follow up | Certainty of the evidence (GRADE) | Relative effect (95% CI) | Anticipated absolute effects* (95% CI) | |
| Risk with on demand placebo or no treatment | Risk difference with scheduled PDE5I | ||||
| Self‐reported potency ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ |
| Erectile function ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ |
| Serious adverse events ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ |
| Sexual quality of life assessed with: Expanded Prostate Cancer Index Composite (sexual domain) Scale from: 0 (worst) to 100 (best) follow up: mean 54 weeks | 280 (1 RCT) | ⊕⊕⊕⊝ MODERATE 1 | ‐ | The mean quality of life was 33.4 | MD 3.2 higher (5.91 lower to 12.31 higher) |
| Treatment discontinuation follow up: mean 54 weeks | 420 (1 RCT) | ⊕⊕⊕⊝ MODERATE 1 | RR 1.12 (0.85 to 1.48) | Study population | |
| 310 per 1,000 | 37 more per 1,000 (46 fewer to 149 more) | ||||
| International Index of Erectile Function ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ |
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; OR: Odds ratio; | |||||
| GRADE Working Group grades of evidence High certainty: We are very confident that the true effect lies close to that of the estimate of the effect Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect | |||||
1 Downgraded by one level for imprecision: confidence interval crosses assumed threshold of clinically important difference.