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. 2018 Oct 3;2018(10):CD002102. doi: 10.1002/14651858.CD002102.pub3

1. Classification of colorectal cancers according to TNM (T stage: local invasion depth; N stage: lymph node involvement; and M stage: presence of distant metastases).

  Definition
T stage
Tx No information about local tumour infiltration available
Tis Tumour restricted to mucosa, no infiltration of lamina muscularis mucosae.
T1 Infiltration through lamina muscularis mucosae into submucosa, no infiltration of lamina muscularis propria
T2 Infiltration into, but not beyond, lamina muscularis propria
T3 Infiltration into subserosa or non‐peritonealised pericolic or perirectal tissue, or both; no infiltration of serosa or neighbouring organs
T4a Infiltration of the serosa
T4b Infiltration of neighbouring tissues or organs
N stage
Nx No information about lymph node involvement available
N0 No lymph node involvement
N1a Cancer cells detectable in 1 regional lymph node
N1b Cancer cells detectable in 2 to 3 regional lymph nodes
N1c Tumour satellites in subserosa or pericolic or perirectal fat tissue, regional lymph nodes not involved
N2a Cancer cells detectable in 4 to 6 regional lymph nodes
N2b Cancer cells detectable in 7 or greater regional lymph nodes
M stage
Mx No information about distant metastases available
M0 No distant metastases detectable
M1a Metastasis to 1 distant organ or distant lymph nodes
M1b Metastasis to more than 1 distant organ or set of distant lymph nodes or peritoneal metastasis