Comparison 1. Tricylic antidepressant versus placebo ‐ final follow‐up values used.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in depressive symptoms	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
2 Adverse events	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
2.1 Disease‐related events: all physical symptoms	1		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
2.2 Disease‐related events: breathlessness symptoms	1		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
3 Change in quality of life ‐ overall score	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
4 Change in dyspnoea (Pulmonary Functional Status Instrument)	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
4.1 Global day‐to‐day ratings ‐ today	1		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
4.2 Global day‐to‐day ratings ‐ with most day‐to‐day activities	1		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
4.3 Global day‐to‐day ratings ‐ most days	1		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
4.4 During 81 activities of daily living ‐ low demand	1		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
4.5 During 81 activities of daily living ‐ moderate demand	1		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
4.6 During 81 activities of daily living ‐ high demand	1		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
4.7 At end of walk	1		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
4.8 Change during walk	1		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]