Comparison 2. Selective serotonin reuptake inhibitor versus placebo ‐ final follow‐up values used.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in depressive symptoms	2	148	Std. Mean Difference (IV, Random, 95% CI)	0.75 [‐1.14, 2.64]
2 Adverse events	3		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 Nausea	3	171	Odds Ratio (M‐H, Random, 95% CI)	2.32 [0.66, 8.12]
2.2 Dizziness	2	143	Odds Ratio (M‐H, Random, 95% CI)	0.61 [0.09, 4.06]
3 Change in FEV1	2	148	Mean Difference (IV, Random, 95% CI)	0.01 [‐0.03, 0.05]
4 Change in quality of life	2	148	Std. Mean Difference (IV, Random, 95% CI)	1.17 [‐0.80, 3.15]
5 Change in exercise tolerance	2	148	Mean Difference (IV, Random, 95% CI)	13.88 [11.73, 16.03]