Li 2015a.
Methods | Allocation: randomised Blinding: not addressed Location: community care, China Length of follow‐up: 1 year |
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Participants | Diagnosis: chronic schizophrenia (CCMD‐3) N = 100 Sex: 48 M, 44 F Age: 18 ‐ 60 years, mean ˜ 37.3 years, SD ˜ 10 years Included: length of illness: mean ˜ 14 years, SD ˜ 10.9 years; length of illness > 5 years, state of the illness was stabilised and medication was continued, living in community and taken care by at least one of the direct relatives Excluded: mental retardation, serious physical disease, pregnancy or lactation |
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Interventions | 1. CBT group*: N = 48 Content: functional analysis of symptoms and negative behaviour, providing treatment therapy, to help participants to develop positive attitudes, improve cognitive abilities, reduce conflicts with social interaction, improve clinical compliance, reduce negative mood, improve the way of thinking Delivered by: specially trained therapists Frequency: A 50‐minute CBT was conducted twice weekly in the first 6 months, once per week in the next 6 months, with a specialist coming weekly in assistance with the therapies. Treatment duration: 1 year 2. Standard care group**: N = 44 Content: not reported Delivered by: not reported Frequency: not reported Treatment duration: 1 year |
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Outcomes | Mental state: general (SCL‐90 scores) Satisfaction with treatment: leaving the study early Unable to use: Mental state: depression, anxiety, psychotic symptoms, somatisation, sensitivity of interpersonal relationships, obsessive‐compulsive disorder, hostility, paranoia, phobia (SCL‐90 scores) ‐ skewed data Burden: family burden scale score for relatives of the participant (not predefined outcome for this review) |
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Notes | *Participants in the CBT group also received the standard care intervention. **The term 'Control' was used for the comparator group with no further details given. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Quote: "Randomisation was carried out by using random number table." (p.2) Comments: The investigators described a random component in the sequence generation process. |
Allocation concealment (selection bias) | Unclear risk | Comments: The author did not describe allocation concealment. Insufficient information to permit judgement of 'Low risk' or 'High risk' |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Comments: The author did not describe the blinding of participants and personnel. However, as the CBT was based on standard care, participants and personnel were not likely to be blinded. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Comments: The author did not describe the blinding of outcome assessment. Insufficient information to permit judgement of 'Low risk' or 'High risk'. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Comments: 2 participants in the CBT group and 6 participants in the standard care group dropped out during the study, due to the participants or relatives refusing treatment. |
Selective reporting (reporting bias) | Low risk | Comments: All measured outcomes were reported. |
Other bias | Low risk | Comments: none obvious. The study was funded by Chang Zhou scientific project funding from the Department of Science and Technology of Jiangsu province, no. CS20102013. |