Friedland 2008.

Methods	Study design: prospective, randomized, double‐blind, controlled clinical trial Study duration: December 2004 to April 2006 Follow‐up: 60 min
Participants	Country: not stated Setting: single urban ED Annual census: 80,000 Inclusion criteria: aged ≥ 18 years, acute nausea or vomiting Exclusion criteria: hepatic disease, head trauma, small bowel obstruction, fever > 100.2 °F (37.2 °C), severe abdominal pain, gastrointestinal bleed, hernia Number: treatment group 1: 32; treatment group 2: 35 Median age, IQR (years): combined both groups 33 (IQR not reported) Sex (M/W): combined both groups 72% women
Interventions	Treatment group 1: granisetron 0.1 mg IV Treatment group 2: prochlorperazine 10 mg IV
Outcomes	Main outcomes: change in nausea VAS at 30 and 60 min, rescue medication use
Notes	Data reported in abstract only Results: change in nausea VAS at 30 min was group 1 ‐34.6 mm (95% CI ‐43.2 to ‐26.1), group 2 ‐35.5 mm (95% CI ‐44.3 to ‐26.7), at 60 min was ‐47.6 mm (95% CI ‐57.7 to ‐37.4) and ‐45.6 mm (95% CI ‐54.5 to ‐36.8). "No difference in rescue medication use"