| Index test | Studies | Cases/Number of participants | Summary sensitivity (95% CI) % | Summary specificity (95% CI) % |
| Primary target condition: Invasive melanoma andatypical intraepidermal melanocytic variants | ||||
| MSI‐CAD | 7 | 281/2389 | 93.7 (83.9 to 97.7) | 41.7 (22.0 to 64.6) |
| Derm‐CAD | 19 | 955/8403 | 88.5 (81.3 to 93.1) | 71.3 (60.0 to 80.4) |
| DB–MIPS | 4 | 427/1479 | 96.4 (84.9 to 99.2) | 85.5 (75.7 to 91.7) |
| MelaFind | 4 | 191/1786 | 97.9 (94.6 to 99.2) | 24.8 (8.82 to 52.9) |
| Secondary target condition: Invasive melanoma alone | ||||
| MSI‐CAD | 4 | 80/256 | 83.1 (26.5 to 98.5) | 66.9 (41.6 to 85.1) |
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