Comparison 1. Mefloquine versus sulfadoxine‐pyrimethamine.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Clinical malaria episodes during pregnancy	2		Rate Ratio (Fixed, 95% CI)	0.83 [0.65, 1.05]
2 Maternal peripheral parasitaemia at delivery	2	5455	Risk Ratio (M‐H, Fixed, 95% CI)	0.65 [0.48, 0.86]
3 Placental malaria	2	4668	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.58, 1.86]
4 Mean haemoglobin at delivery	2	5588	Mean Difference (IV, Fixed, 95% CI)	0.10 [0.01, 0.19]
5 Maternal anaemia at delivery	2	5469	Risk Ratio (M‐H, Fixed, 95% CI)	0.84 [0.76, 0.94]
6 Severe maternal anaemia at delivery	2	5469	Risk Ratio (M‐H, Random, 95% CI)	0.93 [0.58, 1.48]
7 Cord blood parasitaemia	2	5309	Risk Ratio (M‐H, Random, 95% CI)	0.44 [0.13, 1.46]
8 Cord blood anaemia	1	4006	Risk Ratio (M‐H, Fixed, 95% CI)	1.04 [0.87, 1.23]
9 Mean birth weight	2	5241	Mean Difference (IV, Fixed, 95% CI)	2.52 [‐25.66, 30.69]
10 Low birth weight	2	5641	Risk Ratio (M‐H, Random, 95% CI)	0.95 [0.78, 1.17]
11 Low birth weight by gravidity	2	5641	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.84, 1.13]
11.1 Primigravidae	2	1576	Risk Ratio (M‐H, Fixed, 95% CI)	1.02 [0.80, 1.30]
11.2 Multigravidae	2	4065	Risk Ratio (M‐H, Fixed, 95% CI)	0.94 [0.78, 1.14]
12 Prematurity	2	4640	Risk Ratio (M‐H, Fixed, 95% CI)	1.03 [0.76, 1.40]
13 Malaria in first year of life	1		Rate Ratio (Fixed, 95% CI)	0.97 [0.82, 1.15]
14 Hospital admissions in first year of life	1		Rate Ratio (Fixed, 95% CI)	0.93 [0.75, 1.17]
15 SAEs during pregnancy	1	4674	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.81, 1.20]
16 Stillbirths and abortions	2	6219	Risk Ratio (M‐H, Fixed, 95% CI)	1.20 [0.91, 1.58]
17 Congenital malformations	2	5931	Risk Ratio (M‐H, Random, 95% CI)	1.10 [0.51, 2.37]
18 Maternal mortality	2	6219	Risk Ratio (M‐H, Random, 95% CI)	2.41 [0.27, 21.23]
19 Neonatal mortality	2	6134	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.67, 1.43]
20 Infant mortality	1		Rate Ratio (Fixed, 95% CI)	1.00 [0.66, 1.52]
21 AEs: vomiting	2	6272	Risk Ratio (M‐H, Fixed, 95% CI)	4.76 [4.13, 5.49]
22 AEs: fatigue/weakness	2	6272	Risk Ratio (M‐H, Random, 95% CI)	4.62 [1.80, 11.85]
23 AEs: dizziness	2	6272	Risk Ratio (M‐H, Random, 95% CI)	4.21 [3.36, 5.27]
24 AEs: headache	2	6272	Risk Ratio (M‐H, Random, 95% CI)	0.70 [0.25, 1.94]