Comparison 2. Mefloquine plus cotrimoxazole versus cotrimoxazole.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Clinical malaria episodes during pregnancy	1		Rate Ratio (Fixed, 95% CI)	0.76 [0.33, 1.76]
2 Maternal peripheral parasitaemia at delivery (PCR)	2	989	Risk Ratio (M‐H, Fixed, 95% CI)	0.52 [0.30, 0.93]
3 Placental malaria (blood smear)	2	1144	Risk Ratio (M‐H, Fixed, 95% CI)	0.51 [0.29, 0.89]
4 Placental malaria (PCR)	2	977	Risk Ratio (M‐H, Fixed, 95% CI)	0.28 [0.14, 0.57]
5 Mean haemoglobin at delivery	2	1167	Mean Difference (IV, Random, 95% CI)	0.07 [‐0.32, 0.46]
6 Maternal anaemia at delivery (< 9.5 g/dL)	2	1197	Risk Ratio (M‐H, Fixed, 95% CI)	0.94 [0.73, 1.20]
7 Maternal severe anaemia at delivery	2	1167	Risk Ratio (M‐H, Fixed, 95% CI)	0.93 [0.41, 2.08]
8 Cord blood parasitaemia	2	1166	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.03, 3.13]
9 Mean birth weight	2	1220	Mean Difference (IV, Random, 95% CI)	‐25.75 [‐86.99, 35.49]
10 Low birth weight	2	1220	Risk Ratio (M‐H, Fixed, 95% CI)	1.20 [0.89, 1.60]
11 Prematurity	2	824	Risk Ratio (M‐H, Random, 95% CI)	1.07 [0.58, 1.96]
12 SAEs during pregnancy	2	1347	Risk Ratio (M‐H, Fixed, 95% CI)	0.69 [0.50, 0.95]
13 Spontaneous abortions and stillbirths	2	1347	Risk Ratio (M‐H, Random, 95% CI)	1.12 [0.42, 2.98]
14 Congenital malformations	2	1312	Risk Ratio (M‐H, Fixed, 95% CI)	0.61 [0.22, 1.67]
15 Maternal mortality	2	1347	Risk Ratio (M‐H, Fixed, 95% CI)	0.51 [0.13, 2.01]
16 Neonatal mortality	2	1239	Risk Ratio (M‐H, Fixed, 95% CI)	1.32 [0.65, 2.69]
17 Mother‐to‐child transmission HIV	2	1019	Risk Ratio (M‐H, Fixed, 95% CI)	1.92 [1.13, 3.25]
18 AEs: vomiting	2	1347	Risk Ratio (M‐H, Random, 95% CI)	20.88 [1.40, 311.66]
19 AEs: fatigue/weakness	2	1347	Risk Ratio (M‐H, Random, 95% CI)	2.95 [0.26, 32.93]
20 AEs: dizziness	2	1347	Risk Ratio (M‐H, Random, 95% CI)	16.34 [0.39, 684.99]
21 AEs: headache	2	1347	Risk Ratio (M‐H, Random, 95% CI)	0.76 [0.28, 2.10]