1. Review Primary Outcome Results.

Study	Protocolized weaning N        mean (SD)		Non‐protocolized weaning N             mean (SD)		Difference in mean	95% CI	P‐value
Foronda 2011	134	111 (85)	126	143 (107)	‐32	‐55.58 to ‐8.42	0.01±
Jouvet 2013	15	200 (186)	15	288 (206)	‐88	‐228.46 to 52.46	0.20§
Maloney 2007	15	93.6 (27)*	16	117.8 (64)*	‐24.2†	‐10.0 to 58.4	0.055||

* Standard deviation approximated from the interquartile range; † difference in median; ± from t‐test; § from Mann Whitney U‐test; || from Mann Whitney t‐test; NR not reported