3. Table of Adverse Events Results.

Study	Protocolized weaning n/N (%)	Non‐protocolized weaning n/N (%)	Risk Ratio	95% CI	P‐value
PICU Mortality
Foronda 2011	23/155 (14.8)	15/139 (10.8)	1.44	0.72 to 2.89	0.30
Jouvet 2013	1/15 (6.7)	0/15 (0.0)	3.0	0.13 to 68.26	NR
Reintubation
Foronda 2011	15/134 (11.2)	18/126 (14.3)	0.78	0.41 to 1.49	0.45
Jouvet 2013	2/15 (13.3)	1/15 (6.7)	2.0	0.2 to 19.78	NR
Maloney 2007	2/15 (13.3)	3/16 (12.5)	0.71	0.14 to 3.68	1.0
Self‐extubation
Foronda 2011	3/134 (2.2)	8/126 (6.3)	0.35	0.1 to 1.3	0.10
Jouvet 2013	1/15 (6.7)	0/15 (0.0)	3.0	0.13 to 68.26	NR
Maloney 2007	0	0	NE	NE	NE
Non‐invasive ventilation post extubation
Foronda 2011	29/134 (21.6)	39/126 (31.0)	0.7	0.46 to 1.06	0.09
Jouvet 2013	1/15 (6.7)	2/15 (13.3)	0.5	0.05 to 4.94	NR
Ventilator‐associated pneumonia
Foronda 2011	9/123 (6.7)	12/126 (9.5)	0.77	0.34 to 1.76	0.41
Prolonged MV
Jouvet 2013	0/15 (0.0)	2/15 (13.3)	0.20	0.01 to 3.85	NR

NE, not estimable; NR, not reported.