Judgement (please circle)	Source (page no in report)
A. Types of study Can the study be described as randomized or quasi‐randomized?	Yes         Unclear       No
B. Participants Were any participants children (18 years or younger)?	Yes         Unclear       No
C. Interventions 1.       Was one group weaned using a formal protocol1? 2.       Was the other group weaned without reference to a formal protocol?	Yes         Unclear       No   Yes         Unclear       No
D. Outcomes Did the study report: 1. Total duration of MV (time from initiation of MV to invasive MV discontinuation as stated by the authors)?   2. Weaning duration (time from identification of weaning readiness to MV discontinuation as stated by the authors)?   3. MV time before weaning (time from initiation of MV to identification of weaning readiness as stated by the authors)?   4. PICU length of stay? 5. Hospital length of stay? 6. Qualtiy of life for participants? 7. Adverse events?	Yes         Unclear       No   Yes         Unclear       No    Yes         Unclear       No   Yes         Unclear       No Yes         Unclear       No Yes         Unclear       No Yes         Unclear       No
Conclusion:  Do not proceed if any answers to A, B or C are ‘No’. Do not proceed if all answers to D are ‘No’.   Excluded and listed in excluded studies table:   Included: (continue to page 2)          More information needed before inclusion decision (specify):   Record for tables: If study to be ‘included' or ‘listed in excluded table’, record below the information to be inserted into tables: