Domain	Description	Review author’s judgement
Sequence generation		Was the sequence adequately generated?           Yes                       Unclear                       No
Allocation concealment		Was allocation adequately concealed?           Yes                       Unclear                       No
Blinding of participants, personnel and outcome assessors Assessments should be made for each main outcome (or class of outcome)		Was knowledge of the allocated intervention adequately prevented during the study?           Yes                       Unclear                       No
Incomplete outcome data   Assessments should be made for each main outcome (or class of outcome)		Were incomplete outcome data adequately addressed?           Yes                       Unclear                       No
Selective outcome reporting		Are reports of the study free of suggestion of selective outcome reporting?           Yes                       Unclear                       No
Other sources of bias		Was the study apparently free of other problems that could put it at high risk?           Yes                       Unclear                       No