Study	Study inclusion	Protocol intervention	Usual care
Foronda 2011	Participants randomly assigned to groups when they met the study inclusion criteria: ·         28 days to 15 years ·         Mechanically ventilated > 24 hours	1. Daily evaluation of readiness to wean with following criteria:   ·         FiO2 ≤ 0.5 ·         PEEP ≤ 8 cm H2O ·         PIP ≤ 25 cm H2O ·         CXR nothing new ·         Respiratory drive ·         No IV sedatives ·         No neuromuscular blockade ·         Electrolytes normal ·         Hemodynamically stable   2. Two‐hour SBT	Weaning according to discretion of medical team with no influence from protocols, usually when following criteria met: ·         Wheezing controlled/ respiratory drive ·         pH ≥ 7.3 ·         FiO2 ≤ 0.4 ·         PEEP ≤ 5 cm H2O ·         PIP ≤ 20 cm H2O ·         CXR nothing new ·         No IV sedatives/neuromuscular blockade ·         Electrolytes normal ·         Haemodynamically stable
Jouvet 2013	Participants randomly assigned to groups when they met the study inclusion criteria AND passed a PS test: ·         2 to 18 years ·         Weight > 15 kg ·         Able to breathe spontaneously ·         No vasopressors/inotropes ·         FiO2 ≤ 0.60 ·         PEEP ≤ 8 cm H2O ·         Plateau pressure ≤ 25 cm H2O ·         PaCO2 < 70 ·         ET tube leak ≤ 20% ·         Ventilator available  PS test: PS ± 5 cm H2O of pre‐inclusion plateau pressure for 30 min. Repeated daily until passed (fail if RR > 40 breaths/min; FiO2 > 0.6 on 95% SaO2)	Weaned using the SmartCare/PS™ computer‐driven explicit computerized protocol. In addition, PEEP was adjusted using a written protocol including the following two guidelines: (1) decrease of PEEP level by 1 cm H2O per 8 hours as far as 5 cm H2O, if FiO2 ≤ 50% with SpO2 ≥ 95%; (2) if FiO2 ≥ 60% to maintain SpO2 ≥ 95% during 1 hour, the attending physician could decide if an increase in PEEP was necessary	Weaned according to individual discretion of medical team without a protocol
Maloney 2007	Participants randomly assigned to groups when they met the study inclusion criteria:  Intubated (oral/nasal) for acute respiratory failure AND the following weaning actions had begun: MV > 48 hours and two consecutive reductions in vT, PEEP, mRR or PS	Computerized decision support tool based on a paper‐based paediatric ventilator weaning protocol Computer system collected real‐time data from other sources. Then using rules (based on the paper protocol), it determined when changes to ventilation were necessary. The computer alerted the RT by using a paging system to log on to view the changes required to the ventilator. Changes were made manually by RTs	Weaned according to personal clinical judgment of the physician