Evans 1976.

Methods	Randomised controlled trial
Participants	44 newborn infants, of gestation 38 to 42 weeks, delivered spontaneously or by forceps, whose mothers had been given pethidine in labour
Interventions	1. Naloxone administered via the umbilical vein at 1 minute of age (0.04 mg total): n = 20 2. No drug: n = 24
Outcomes	Time to first breath, time to onset of sustained respiration, Apgar score at 5 minutes, alveolar carbon dioxide tension, alveolar ventilation, and ventilation rate at 10 minutes and 30 minutes of life
Notes	NICU, Wales, mid 1970s
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Described as "randomly allocated", no further details reported
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding of participants and personnel (performance bias) All outcomes	High risk	Unblinded
Blinding of outcome assessment (detection bias) All outcomes	High risk	Unblinded
Incomplete outcome data (attrition bias) All outcomes	Low risk	Complete follow‐up
Selective reporting (reporting bias)	Unclear risk	No protocol (though no reason to suspect selective reporting)
Other bias	Low risk	No reason to suspect any other bias