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. 2016 May 20;2016(5):CD009491. doi: 10.1002/14651858.CD009491.pub2

Comparison 1. Intravenous midazolam versus diazepam.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Number of participants rated as 'anxious' 2 175 Risk Ratio (M‐H, Fixed, 95% CI) 0.80 [0.39, 1.62]
2 Participant co‐operation (not co‐operative) 4 316 Risk Ratio (M‐H, Random, 95% CI) 0.94 [0.48, 1.84]
3 Participant satisfaction 2 91 Mean Difference (IV, Fixed, 95% CI) 2.17 [‐0.51, 4.85]
4 Proceduralist satisfaction 2 91 Mean Difference (IV, Fixed, 95% CI) 1.09 [‐10.43, 12.60]
5 Difficulty performing procedures (rated as difficult to perform procedure) 3 277 Risk Ratio (M‐H, Fixed, 95% CI) 0.66 [0.41, 1.07]
6 Onset of sedation 2 140 Mean Difference (IV, Random, 95% CI) ‐1.80 [‐3.76, 0.16]
7 Anterograde amnesia (defined as the number of participants who recalled procedure) 9 587 Risk Ratio (M‐H, Random, 95% CI) 0.45 [0.30, 0.66]
8 Quality of recovery (rated as delayed recovery) 3 166 Risk Ratio (M‐H, Random, 95% CI) 0.72 [0.08, 6.63]
9 Discomfort/Pain 5 415 Risk Ratio (M‐H, Random, 95% CI) 0.60 [0.24, 1.49]