Aktogu 1994.
Methods | Parallel‐group single‐centre randomized controlled trial conducted in Turkey | |
Participants | 32 adults undergoing bronchoscopy (mean age midazolam group 49.4 ± 13.3 and diazepam group 50.9 ± 12.1; 50% men in both groups) | |
Interventions | Midazolam 0.06 mg/kg administered intravenously Diazepam 0.15 mg/kg administered intravenously |
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Outcomes |
Measured 5 and 10 minutes after start of procedure: Level of sedation on a sedation assessment scale (only the percentage of participants who scored in the 'awake' rank of a sedation scale that ranged from 0 to 4 (0 = awake and 4 = reactive to pain but no verbal communication) that was measured 5 minutes after sedation was administered) Measured 24 hours after procedure: Anterograde amnesia (defined by number of participants who recalled the procedure) |
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Notes | Conflicts of interest or funding sources were not reported. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Unclear (no mention of randomization method, just a statement that participants were randomized) |
Allocation concealment (selection bias) | Unclear risk | Unclear (no mention of allocation method, just a statement that participants were randomized) |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Unclear (no mention) |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Only statistical analysis of the questionnaires was reported to have been performed by a blinded statistician |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No withdrawals |
Selective reporting (reporting bias) | Unclear risk | No clear evidence that measured outcomes were not reported (trial protocols were not sought for confirmation) |
Other bias | Low risk | None expected |