| Methods |
Parallel‐group single‐centre randomized controlled trial conducted in the UK |
| Participants |
102 adults undergoing upper gastrointestinal endoscopy (mean age midazolam group was 62.8 ± 16.1 years and 65.8 ± 11.5 in the diazepam group) |
| Interventions |
Intravenous midazolam 2.5 mg or 1 mg for elderly (mean 6.0 ± 2.8) vs intravenous diazepam 5 mg or 2 mg for elderly (mean 11.5 ± 6.7) |
| Outcomes |
Vital signs (change in oxygen saturation from baseline to post‐sedation) |
| Notes |
Conflicts of interest or funding sources were not reported |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Not reported |
| Allocation concealment (selection bias) |
Unclear risk |
No information |
| Blinding of participants and personnel (performance bias)
All outcomes |
Unclear risk |
Not blinded |
| Blinding of outcome assessment (detection bias)
All outcomes |
Unclear risk |
Not blinded |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
No withdrawals |
| Selective reporting (reporting bias) |
Unclear risk |
No clear evidence that measured outcomes were not reported (trial protocols were not sought for confirmation) |
| Other bias |
Low risk |
None expected |
