Bhalla 2006.

Methods	Parallel‐group single‐centre randomized controlled trial conducted in India in 2000
Participants	252 adults undergoing diagnostic or therapeutic upper gastrointestinal endoscopy. Authors stated that there were no difference in baseline characteristics of the 3 groups
Interventions	1) Intravenous midazolam 5 mg (3 mg if older than 65) 2) Intravenous diazepam 5 mg (3 mg if older than 65) 3) Intravenous saline (placebo)
Outcomes	Measured during the procedure: Vital signs (minimum oxygen saturation) Vital signs (oxygen desaturation < 90%) Vital signs (tachycardia defined as heart rate > 140 bpm) Vital signs (bradycardia) Vital signs (hypertension defined as systolic blood pressure > 200 mmHg) Incomplete procedures Difficulty performing procedure Discomfort/pain
Notes	Conflicts of interest or funding sources were not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"Block randomisation"
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Endoscopist and investigator recording haemodynamic data were not aware of the nature of the medications
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Endoscopist and investigator recording haemodynamic data were not aware of the nature of the medications
Incomplete outcome data (attrition bias) All outcomes	Low risk	No loss to follow‐up reported
Selective reporting (reporting bias)	Unclear risk	No clear evidence that measured outcomes were not reported (trial protocols were not sought for confirmation)
Other bias	Low risk	None expected