Bianchi Porro 1988.

Methods	Single‐centre cross‐over randomized controlled trial conducted in Italy
Participants	23 adults undergoing upper gastrointestinal endoscopy (14 men and 9 women; mean weight 60.7 kilograms; age range 20 to 48 years; mean age 32.5)
Interventions	1) Intravenous midazolam 0.07 mg/kg 2) Intravenous Diazepam 0.15 mg/kg
Outcomes	Measured during the procedure: Vital signs (blood pressure 5 minutes after sedation) Vital signs (heart rate 5 minutes after sedation Level of sedation using a sedation assessment scale 4 Participant co‐operation Measured 2 hours after the procedure: Quality of recovery Measured 24 hours after the procedure: Anterograde amnesia (defined by number of participants who recalled the procedure)
Notes	At least 30 days between procedures We were unable to locate contact details of the authors to access pre‐cross‐over data Conflicts of interest or funding sources were not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not reported
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Drugs prepared and administered by physician not performing endoscopy or assessments
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Drugs prepared and administered by physician not performing endoscopy or assessments
Incomplete outcome data (attrition bias) All outcomes	Low risk	No withdrawals
Selective reporting (reporting bias)	Unclear risk	No clear evidence that measured outcomes were not reported (trial protocols were not sought for confirmation)
Other bias	Low risk	None expected