Gilvarry 1990.
Methods | Single‐centre parallel‐group randomized controlled trial conducted in the United Kingdom | |
Participants | 60 adults undergoing upper gastrointestinal endoscopy (mean age: 41.4 in diazepam group and 42.2 in midazolam group; 46% men in diazepam group and 43% men in diazepam group) | |
Interventions | 10 mg intravenous midazolam 20 mg intravenous diazepam |
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Outcomes |
Measured 24 hours after the procedure: Participant satisfaction (measured in the trial as the participant considered sedation was inadequate) Anterograde amnesia (recalled procedures) |
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Notes | Conflicts of interest or funding sources were not reported | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | "Stratified randomised order" |
Allocation concealment (selection bias) | Unclear risk | Not reported |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Not blinded |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | An author who did not know which medication had been administered assessed outcomes 24 hours after the procedure |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No withdrawals |
Selective reporting (reporting bias) | Unclear risk | No clear evidence that measured outcomes were not reported (trial protocols were not sought for confirmation) |
Other bias | Low risk | None expected |