Rolo 2012.

Methods	Multicentre (2 sites) parallel‐group randomized controlled trial conducted in Portugal
Participants	100 adults undergoing fibreoptic bronchoscopy (Mean age was 56 ± 14 years (range 18 ‐ 79 years); 66% were men
Interventions	0.05 mg/kg intravenous midazolam Placebo
Outcomes	Measured during the procedure: Level of sedation on a sedation assessment scale Vitals signs Disinhibition/excitation (measured in the trial as 'agitation') Sedation reversal Measured 1 hour after the procedure: Participant satisfaction (willingness to undergo another procedure with the same medication)
Notes	Conflicts of interest or funding sources were not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not reported
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Did state it was double‐blind but no specific information provided about how this was achieved
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not reported
Incomplete outcome data (attrition bias) All outcomes	Low risk	No withdrawals
Selective reporting (reporting bias)	Unclear risk	No clear evidence that measured outcomes were not reported (trial protocols were not sought for confirmation)
Other bias	Low risk	None expected