Sainpy 1984.

Methods	Parallel‐group single‐centre randomized controlled trial conducted in France
Participants	64 adults who underwent a gastroduodenal endoscopy. Exclusion of myasthenia gravis, pregnancy, past history of adverse reaction to benzodiazepines, long‐term treatment with psychotropes
Interventions	Intravenous midazolam: 0.1 mg under 65 yrs and 0.085 mg over 65 yrs infused in 30 seconds Intravenous diazepam: 0.2 mg under 65 yrs and 0.15 mg over 65 yrs infused in 30 seconds
Outcomes	Measured during the procedure: Discomfort/pain Measured after the procedure Duration of sedation Anterograde amnesia (defined by number of participants who recalled the procedure)
Notes	Conflicts of interest or funding sources were not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Method not stated
Allocation concealment (selection bias)	Low risk	Used sealed envelopes
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	The gastroenterologist was the only person blinded to sedative drug
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	The gastroenterologist was the only person blinded to sedative drug
Incomplete outcome data (attrition bias) All outcomes	Low risk	No withdrawals
Selective reporting (reporting bias)	Unclear risk	No clear evidence that measured outcomes were not reported (trial protocols were not sought for confirmation)
Other bias	Low risk	None expected