Takrouri 1988.

Methods	Single‐centre parallel‐group randomized controlled trial conducted in Jordan
Participants	120 adults undergoing endoscopy (mean age 39 ± 0.6 in diazepam group, 41 ± 0.9 in flunitrazepam group and 34 ± 0.6 in midazolam group)
Interventions	Mean doses: diazepam 5 mg; flunitrazepam 0.65 mg; midazolam 5.8 mg (all intravenous)
Outcomes	Measured during the procedure: Level of sedation on a sedation assessment scale Number of participants rated as 'anxious' Difficulty performing procedure (rated as difficult to perform procedure) Participant co‐operation (not co‐operative) Measured after the procedure (before discharge): Anterograde amnesia (defined by number of participants who recalled the procedure) Quality of recovery (rated as delayed recovery)
Notes	Conflicts of interest or funding sources were not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random‐number table
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding of participants and personnel (performance bias) All outcomes	High risk	Not blinded
Blinding of outcome assessment (detection bias) All outcomes	High risk	Not blinded
Incomplete outcome data (attrition bias) All outcomes	Low risk	Withdrawals not reported
Selective reporting (reporting bias)	Unclear risk	No clear evidence that measured outcomes were not reported (trial protocols were not sought for confirmation)
Other bias	Low risk	None expected