Tolia 1990.

Methods	Single‐centre parallel‐group randomized controlled trial conducted in USA
Participants	41 children undergoing upper GI endoscopy
Interventions	Intravenous administration of: 1) 0.1 ‐ 0.15 mg/kg midazolam 2) 0.2 ‐ 0.4 mg/kg diazepam
Outcomes	Measured during procedures: Participant co‐operation Measured 24 hours after procedures: Anterograde amnesia (recalled procedures) Discomfort, pain
Notes	Conflicts of interest or funding sources were not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not reported
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Both endoscopist and participant were blinded
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Both endoscopist and participant were blinded
Incomplete outcome data (attrition bias) All outcomes	High risk	Not analysed as intention‐to‐treat
Selective reporting (reporting bias)	Unclear risk	No clear evidence that measured outcomes were not reported (trial protocols were not sought for confirmation)
Other bias	Low risk	None expected