Whitwam 1983.

Methods	Single‐centre parallel‐group randomized controlled trial conducted in the United Kingdom
Participants	100 adult ASA I ‐ II participants undergoing upper GI endoscopy (29 men (58%) in midazolam group and 30 men (60%) in diazepam group; mean age 42 ± 19.9 in midazolam group and 44 ± 18.5 in diazepam group)
Interventions	Intravenous administration of: 1) midazolam 0.07 mg/kg 2) diazepam 0.15 mg/kg
Outcomes	Measured during the procedure: Number of participants rated as 'anxious' Difficulty performing procedure Participant co‐operation Onset of sedation Offset of sedation Oversedation Measured on discharge from recovery area: Anterograde amnesia (recalled procedures) Measured after the procedure (questionnaire sent to participants ‐ no timeframe reported) Quality of recovery
Notes	Reported that 2 of the authors were supported by Roche Inc.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not reported
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not reported
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Blind to investigators assessing participants
Incomplete outcome data (attrition bias) All outcomes	Low risk	No withdrawals
Selective reporting (reporting bias)	Unclear risk	No clear evidence that measured outcomes were not reported (trial protocols were not sought for confirmation)
Other bias	Low risk	None expected