Younge 2001.

Methods	Single‐centre parallel‐group randomized controlled trial conducted in the United Kingdom
Participants	59 children ages 1 to 7 needing laceration repair (mean age 4.1 years in both groups; 54% boys in midazolam group and 53% boys in ketamine group)
Interventions	Oral midazolam 0.7 mg/kg Oral ketamine 10 mg/kg
Outcomes	Measured during the procedure: Level of sedation on a sedation assessment scale Offset time of sedation Vital signs Disinhibition/excitation
Notes	Reported that there were no conflicts of interest or funding received for the trial
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Drug solutions were pre‐prepared by the hospital pharmacy and numbered sequentially, randomly containing 1 or other drug
Allocation concealment (selection bias)	Low risk	Drug solutions were pre‐prepared by the hospital pharmacy and numbered sequentially, randomly containing 1 or other drug
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double‐blind
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Double‐blind
Incomplete outcome data (attrition bias) All outcomes	Low risk	No withdrawals
Selective reporting (reporting bias)	Unclear risk	No clear evidence that measured outcomes were not reported (trial protocols were not sought for confirmation)
Other bias	Low risk	None expected