Yuno 1996.

Methods	Single‐centre parallel‐group randomized controlled trial conducted in Japan
Participants	40 adults undergoing colonoscopy for polyp removal
Interventions	0.05 mg/kg intravenous midazolam Placebo
Outcomes	Measured during the procedure: Level of sedation on a sedation assessment scale Participant satisfaction (measured in the trial as participant‐assessed adequacy of sedation) Proceduralist satisfaction (measured in the trial as proceduralist‐assessed adequacy of sedation) Vital signs
Notes	Reported that a grant from the Osaka Association for Prevention of Adult Diseases funded the study. No conflicts of interest were reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not reported
Allocation concealment (selection bias)	Low risk	"Envelope method"
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Noted it was double‐blind but no specific information provided
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Noted it was double‐blind but no specific information provided
Incomplete outcome data (attrition bias) All outcomes	Low risk	No withdrawals reported
Selective reporting (reporting bias)	Unclear risk	No clear evidence that measured outcomes were not reported (trial protocols were not sought for confirmation)
Other bias	Low risk	No withdrawals reported

ASA: American Society of Anesthesiology
 BPM: beats per minute
 GI; gastrointestinal
 HR: heart rate
 MRI: magnetic resonance Imaging
 RCT: randomized controlled trial
 SBP: systolic blood pressure