2. Adverse effects reported in studies.
| Adverse events | Standard glucose solution | Low GDP solution | Studies reporting outcome | ||
| No. events | No. at risk | No. events | No. at risk | ||
| Neutral pH, low GDP PD solution (excluding peritonitis, death) | |||||
| Exit site infection | 6 0 1 |
91 19 36 |
4 5 3 |
91 40 37 |
balANZ 2010 Coles 1997 Feriani 1998 |
| Tunnel infection | 2 | 91 | 1 | 91 | balANZ 2010 |
| Non‐PD related infection/general infection | 20 0 |
91 19 |
4 6 |
91 40 |
balANZ 2010 Coles 1997 |
| Inadequate dialysis | 1 | 91 | 1 | 91 | balANZ 2010 |
| Fluid overload/hypervolaemia | 3 1 2 |
91 19 36 |
1 4 0 |
91 40 37 |
balANZ 2010 Coles 1997 Feriani 1998 |
| Hypertension | 2 1 |
19 36 |
3 0 |
40 37 |
Coles 1997 Feriani 1998 |
| Hypotension | 0 | 36 | 1 | 37 | Feriani 1998 |
| Hernia | 11 1 |
91 36 |
10 0 |
91 37 |
balANZ 2010 Feriani 1998 |
| Peritoneal leak | 3 | 91 | 1 | 91 | balANZ 2010 |
| Catheter blockage | 4 | 91 | 5 | 91 | balANZ 2010 |
| Malposition | 2 | 91 | 1 | 91 | balANZ 2010 |
| Gastrointestinal disorder | 6 | 91 | 14 | 91 | balANZ 2010 |
| Abdominal pain | 0 | 19 | 3 | 40 | Coles 1997 |
| Pancreatitis | 1 | 36 | 0 | 37 | Feriani 1998 |
| Enteritis | 0 | 36 | 2 | 37 | Feriani 1998 |
| Vomiting | 0 | 36 | 1 | 37 | Feriani 1998 |
| Newly diagnosed cancer | 3 | 91 | 4 | 91 | balANZ 2010 |
| Arthritis | 1 | 36 | 0 | 37 | Feriani 1998 |
| Angina | 0 | 36 | 1 | 37 | Feriani 1998 |
| Apoplexy | 1 | 36 | 1 | 37 | Feriani 1998 |
| Hypercalcaemia | 0 3 |
19 36 |
3 2 |
40 37 |
Coles 1997 Feriani 1998 |
| Hypocalcaemia | 0 | 19 | 3 | 40 | Coles 1997 |
| Hyperphosphataemia | 3 | 19 | 4 | 40 | Coles 1997 |
| Hyperglycaemia | 1 | 36 | 0 | 37 | Feriani 1998 |
| Glucose polymer (icodextrin) (excluding rash, peritonitis, death) | |||||
| Abdominal discomfort | 1 | 103 | 0 | 98 | Lin 2009a |
| Anaemia | 24 26 |
29 112 |
6 39 |
30 175 |
Paniagua 2008 Wolfson 2002 |
| Arterial emboli | 1 | 103 | 0 | 106 | MIDAS 1994 |
| Cardiac failure | 1 | 103 | 1 | 106 | MIDAS 1994 |
| Cerebrovascular accident | 0 | 103 | 2 | 106 | MIDAS 1994 |
| Diabetic foot | 5 | 29 | 1 | 30 | Paniagua 2008 |
| Dizzy | 0 | 103 | 1 | 98 | Lin 2009a |
| Electrolyte disturbances | 4 | 29 | 1 | 30 | Paniagua 2008 |
| Exit site infection | 3 24 |
27 112 |
4 28 |
33 175 |
STARCH 2015 Wolfson 2002 |
| Fatigue | 0 | 103 | 2 | 98 | Lin 2009a |
| Fluid overload | 17 17 |
132 29 |
6 5 |
136 30 |
Lin 2009a Paniagua 2008 |
| Headache | 9 | 112 | 25 | 175 | Wolfson 2002 |
| Stroke | 1 | 27 | 0 | 33 | STARCH 2015 |
| Hyperglycaemia | 27 | 29 | 8 | 30 | Paniagua 2008 |
| Hypotension | 28 | 215 | 25 | 273 |
Lin 2009a Wolfson 2002 |
| Myocardial infarction | 4 3 |
103 29 |
2 0 |
106 30 |
MIDAS 1994 Paniagua 2008 |
| Pain | 18 | 112 | 30 | 175 | Wolfson 2002 |
| Pleural effusion | 6 | 29 | 1 | 30 | Paniagua 2008 |
| Pneumonia | 0 | 103 | 1 | 106 | MIDAS 1994 |
| Pulmonary embolism | 0 | 103 | 1 | 106 | MIDAS 1994 |
| Thirsty | 0 | 103 | 1 | 98 | Lin 2009a |
| Uncontrolled hypertension | 0 21 |
103 112 |
1 40 |
106 175 |
MIDAS 1994 Wolfson 2002 |
| Hypotension | 1 | 27 | 3 | 33 | STARCH 2015 |
| Hypertension | 0 | 27 | 1 | 33 | STARCH 2015 |
| Congestion | 1 | 27 | 0 | 33 | STARCH 2015 |
| Upper respiratory tract infection | 25 | 112 | 41 | 175 | Wolfson 2002 |
| Vomiting | 1 | 103 | 0 | 98 | Lin 2009a |
GDP ‐ glucose degradation products; PD ‐ peritoneal dialysis