Bajo 2011.

Methods	Study design: parallel RCT Study duration: 4 years Follow‐up period: 24 months
Participants	Country: Spain Setting: multicentre (2 sites), university hospital Incident adult CAPD patients Number: treatment group (13); control group (20) Mean age ± SD (years): treatment group (62 ± 11); control group (59 ± 15) Sex (M/F): treatment group (10/3); control group (9/11) Exclusion criteria: none
Interventions	Treatment group Balance (Fresenius Medical Care) Control group Standard PD fluid (Stay Safe)
Outcomes	Peritonitis rate Peritoneal UF (4 hours, 4.25% glucose solution) RRF Patient survival
Notes	Supported by grants from RETICS from Instituto de Salud Carlos III and unrestricted grant from Fresenius Medical Care
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	Quote: "patients were alternately assigned to either 'balance' or standard PD fluid depending on the time point of inclusion"
Allocation concealment (selection bias)	High risk	Quote: "patients were alternately assigned to either 'balance' or standard PD fluid depending on the time point of inclusion"
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	High risk	High drop‐out rate: 21/33 (63.6%)
Selective reporting (reporting bias)	Low risk	All relevant outcomes reported
Other bias	High risk	Outcome parameters significantly different at baseline (e.g. urine volume, RRF)